Bruno Aprea began his musical career as a pianist after studying with his father Tito Aprea at the "Santa Cecilia" School of Music, in Rome. He performed numerous concerts with the Accademia di Santa Cecilia Orchestra, RAI Orchestra of Rome, Milan and Turin, Deutsche Staatsoper in Berlin, and several tours in Italy, Germany and Holland. In 1968, he played Mozart's Concerto in E flat for two pianos and orchestra, in duo with his father, Tito at RAI in Rome under the direction of Sergiu Celibidache. This performance was released on record by Fonit Cetra. In the late 1960's he began studying conducting with Franco Ferrara at the Saint Cecilia School of Music, in Rome and the Accademia Chigiana, in Siena.

His conducting debut was in 1970, at the Two Worlds Festival in Spoleto conducting The Medium, directed by the composer, Gian Carlo Menotti. And after it, he conducted Rigoletto in Amsterdam. In 1977, at Tanglewood Festival, U.S., he got the Koussevitsky Prize (this Prize was given by Leonard Bernstein and Seiji Ozawa, among others).

He has conducted concerts for l'Opéra de Monte Carlo, Théâtre du Châtelet in Paris, RAI of Rome, Milan, Turin and Naples, Israel Chamber Orchestra of Tel Aviv, and Orquestra Sinfônica of São Paolo. Opera engagements include Deutsche Oper Berlin, Cape Town Opera, Wexford Festival (Ireland), Rome Opera, La Fenice (Venice), S. Carlo (Naples), Ravenna, and Ankara. U.S. appearances include Philadelphia ( Don Pasquale), Cincinnati ( Il Trovatore and Lucia di Lammermoor), Baltimore (Carlo Bergonzi's last stage appearance in l'Elisir d'Amore), Denver ( Don Giovanni), Palm Beach ( Don Giovanni and Lucia di Lammermoor), Portland ( Tosca, La Favorita, Don Carlo, Traviata), Columbus ( La fanciulla del West, Rigoletto). Artists who have played under his conducting: J. Achúcarro, R. Orozco, N. Magalof, A. Ciccolini, L. Berman, Kontarsky brothers, d. Ciani, Z. Kocsis, D. Ranki, J.Y. Thibaudet, F. Thiollier, W. Shnaideran, S. Gazzelloni, etc.

Bruno Aprea's conducting activity includes symphonic and lyrical performances. His symphonic repertoire embraces from the 9 Beethoven Symphonies to Stravinsky "Le Sacré du Printemps"; from Haydn and Mozart to Debussy and vanguardist music since 1900; all important composers such as Schubert, Schumann, Brahms, Mahler, etc. And always taking care of no so well known repertoire, he had conducted compositions of rare performance: Beethoven "Christus am Ölberg", Mendelssohn "Die erste Walpurgisnacht", Bruckner "Nullte Symphony", Tchaikovsky "Manfred", etc. (Janacek and Ives as well).

In 80's and 90's, his activity as opera conductor was intensified, after his success in Berlín, 1983, with Madama Butterfly. Maestro Aprea has also recorded a number of rare operas for Nuova Era and Bongiovanni such as Mercadante's Il Bravo, Lauro Rossi's Il Domino Nero, Rossini's La Pietra del Paragone, Puccini's Le Villi, Mascagni's Le Maschere.
In his pedagogic activity, since 1978 he has held the teaching post of Orchestra Conducting, which had been held by his maestro Franco Ferrara at the Saint Cecilia School of Music, in Rome. In these 25 teaching years, the most valuable young italian conductors of the last generation have emerged from his Professorship. He also gives masterclasses in Conducting at the Arts Academy of Rome, in the West Virginia University and in the Morgentown University (USA).

During 2004, 2005 and 2006 he has been giving masterlessons in León (Spain), for Eutherpe Foundation, and in Montreal and Caracas. In 2004, as well he gave guest lectures by Jonde (Joven Orquesta Nacional de España).

Recently, he has become the Artistic Conductor at Palm Beach Opera (Florida) in 2005-2008 period, to conduct operas and symphonic concerts.